The identification of ‘boosters’ that drive gene overexpression directly in a CAR construct provides a simple and scalable strategy for developing effective CAR-NK cell therapies for solid tumours.
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There is a special form for boolean formulas called "Conjunctive Normal Form" (CNF). A problem in this form consists of clauses connected with and operators, where each clause only contains variables connected with or operators. The variables can appear negated, but only variables can be directly negated, something like !(a && b) is not allowed. An example boolean formula in CNF form is:
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